BDBM17278 3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-methylpyridin-2-yl]oxy}benzene-1-carboximidamide::CHEMBL49636::Pyridine template, III::ZK-805623

SMILES Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F

InChI Key InChIKey=ZXIHYCYAQUQHSG-UHFFFAOYSA-N

Data  12 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 17278   

TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Compound was tested for inhibition activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Binding affinity of the compound was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  810nMAssay Description:Inhibitory constant against bovine trypsin for general specificity against serine proteasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  810nMAssay Description:Compound was tested for inhibition activity against bovine trypsin.More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  810nMAssay Description:Inhibitory potency was measured against bovine trypsin.More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  870nM ΔG°:  -8.18kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibitory potency was measured against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibitory constant against human coagulation factor II (thrombin) for selectivity within coagulation cascadeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  2.20E+4nMAssay Description:Compound was tested for inhibition activity against human thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed