BDBM174466 US9688676, 15 (S)-methyl4-(5-(2-((4-amino-2-oxo-3-(4-phenoxyphenyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)methyl)pyrrolidin-1-yl)-4-cyano-2-methyl-5-oxopent-3-en-2-yl)piperazine-1-carboxylate

SMILES COC(=O)N1CCN(CC1)C(C)(C)\C=C(/C#N)C(=O)N1CCC[C@H]1Cn1c2ccnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O

InChI Key InChIKey=MIQARHYSLYNERN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 174466   

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM174466(US9688676, 15 (S)-methyl4-(5-(2-((4-amino-2-oxo-3-...)
Affinity DataIC50: 72nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
US Patent