BDBM175109 US9115117, 11::US9611251, 11

SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1nccc(n1)C(F)(F)F

InChI Key InChIKey=GSJMMIBAIKKQTG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 175109   

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM175109(US9115117, 11 | US9611251, 11)
Affinity DataKi:  634nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM175109(US9115117, 11 | US9611251, 11)
Affinity DataKi:  634nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession numberNM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022) , 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM175109(US9115117, 11 | US9611251, 11)
Affinity DataKi:  9.00E+3nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM175109(US9115117, 11 | US9611251, 11)
Affinity DataKi:  9.00E+3nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent