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BDBM175968 US10047103, 1::US9688695, 1

SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(C)n3)cc(OC)cc2o1

InChI Key: InChIKey=MJOYITBVGFBTNC-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175968   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175968
PNG
(US10047103, 1 | US9688695, 1)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C19H16N4O4S2/c1-10-20-11(9-28-10)8-26-15-4-12(24-2)5-16-13(15)6-17(27-16)14-7-23-18(21-14)29-19(22-23)25-3/h4-7,9H,8H2,1-3H3
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/a25



Bristol-Myers Squibb Co.

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175968
PNG
(US10047103, 1 | US9688695, 1)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C19H16N4O4S2/c1-10-20-11(9-28-10)8-26-15-4-12(24-2)5-16-13(15)6-17(27-16)14-7-23-18(21-14)29-19(22-23)25-3/h4-7,9H,8H2,1-3H3
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/a25



Bristol-Myers Squibb Co.

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)


BindingDB Entry DOI: 10.7270/Q2QF8VWN
More data for this
Ligand-Target Pair