BindingDB logo
myBDB logout

BDBM176277 US10047103, 310::US9688695, 310

SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)C)cc(OC)cc2o1

InChI Key: InChIKey=OVZKCHVQBBNAQT-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 176277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176277
PNG
(US10047103, 310 | US9688695, 310)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C29H27N5O5S2/c1-16(2)33(3)27(35)18-8-6-17(7-9-18)26-30-19(15-40-26)14-38-23-10-20(36-4)11-24-21(23)12-25(39-24)22-13-34-28(31-22)41-29(32-34)37-5/h6-13,15-16H,14H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 0.530n/an/an/a25



Bristol-Myers Squibb Co.

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)


Article DOI: 10.1021/jm049864b
BindingDB Entry DOI: 10.7270/Q2QF8VWN
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176277
PNG
(US10047103, 310 | US9688695, 310)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C29H27N5O5S2/c1-16(2)33(3)27(35)18-8-6-17(7-9-18)26-30-19(15-40-26)14-38-23-10-20(36-4)11-24-21(23)12-25(39-24)22-13-34-28(31-22)41-29(32-34)37-5/h6-13,15-16H,14H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 0.530n/an/an/a25



Bristol-Myers Squibb Co.

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair