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BDBM176746 US9675612, 2 6-[(2-Cyclobutyl[1,3]thiazolo[5,4-d]pyrimidin-7-yl)amino]-1,3-benzothiazol-2(3H)-one

SMILES: O=c1[nH]c2ccc(Nc3ncnc4sc(nc34)C3CCC3)cc2s1

InChI Key: InChIKey=KLERMRAOMZWPMK-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176746
PNG
(US9675612, 2 6-[(2-Cyclobutyl[1,3]thiazolo[5,4-d]p...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4sc(nc34)C3CCC3)cc2s1
Show InChI InChI=1S/C16H13N5OS2/c22-16-20-10-5-4-9(6-11(10)23-16)19-13-12-15(18-7-17-13)24-14(21-12)8-2-1-3-8/h4-8H,1-3H2,(H,20,22)(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 87n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


Article DOI: 10.1021/jm980255b
BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair