BDBM17727 2,6-dimethylphenyl N-(4-methoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate::2-aminopyrimidine carbamate, 26

SMILES COc1ccc(cc1)N(C(=O)Oc1c(C)cccc1C)c1ccnc(Nc2ccc(cc2)N2CCN(C)CC2)n1

InChI Key InChIKey=HLSZVIJXLSHTNC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17727   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM17727(2,6-dimethylphenyl N-(4-methoxyphenyl)-N-(2-{[4-(4...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17727(2,6-dimethylphenyl N-(4-methoxyphenyl)-N-(2-{[4-(4...)
Affinity DataIC50:  420nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM17727(2,6-dimethylphenyl N-(4-methoxyphenyl)-N-(2-{[4-(4...)
Affinity DataIC50:  320nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

LigandPNGBDBM17727(2,6-dimethylphenyl N-(4-methoxyphenyl)-N-(2-{[4-(4...)
Affinity DataIC50:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed