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BDBM177475 US9120749, 841

SMILES: CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2cc(c(cc12)-c1cc(F)c(O)c(Cl)c1)C(F)(F)F)C(=O)C1CC1

InChI Key: InChIKey=OWSODXICOGXEQP-RZDIXWSQNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 177475   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177475
PNG
(US9120749, 841)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2cc(c(cc12)-c1cc(F)c(O)c(Cl)c1)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1/C29H30ClF4N3O2/c1-37(2)14-15-3-7-18(8-4-15)36-26-20-11-19(17-9-23(30)28(39)24(31)10-17)22(29(32,33)34)12-25(20)35-13-21(26)27(38)16-5-6-16/h9-13,15-16,18,39H,3-8,14H2,1-2H3,(H,35,36)/t15-,18-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 770n/an/an/an/a7.425



OncoTherapy Science Inc

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair