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BDBM177495 US9120749, 861

SMILES: CN(C)CC[C@H]1CCC[C@@H](C1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O

InChI Key: InChIKey=RBIUKSNOCNBWKG-RSGSQYTANA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 177495   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177495
PNG
(US9120749, 861)
Show SMILES CN(C)CC[C@H]1CCC[C@@H](C1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1/C27H31Cl2N3O2/c1-16(33)22-15-30-25-8-7-18(19-13-23(28)27(34)24(29)14-19)12-21(25)26(22)31-20-6-4-5-17(11-20)9-10-32(2)3/h7-8,12-15,17,20,34H,4-6,9-11H2,1-3H3,(H,30,31)/t17-,20+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.20n/an/an/an/a7.425



OncoTherapy Science Inc

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair