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BDBM179803 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a)::US10053458, Comparative Example 1

SMILES: CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl

InChI Key: InChIKey=KTEIFNKAUNYNJU-UHFFFAOYSA-N

Data: 6 IC50

PDB links: 10 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 179803   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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PubMed
n/an/a 14.6n/an/an/an/a7.025



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Bioorg Chem 65: 146-58 (2016)


Article DOI: 10.1016/j.bioorg.2016.02.009
BindingDB Entry DOI: 10.7270/Q2VT1QVX
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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Article
PubMed
n/an/a 17.6n/an/an/an/a7.525



Tianjin University of Science and Technology



Assay Description
The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...


Bioorg Chem 65: 146-58 (2016)


Article DOI: 10.1016/j.bioorg.2016.02.009
BindingDB Entry DOI: 10.7270/Q2VT1QVX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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n/an/a 220n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent




US Patent US10053458 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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PubMed
n/an/a 337n/an/an/an/a7.525



Tianjin University of Science and Technology



Assay Description
The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...


Bioorg Chem 65: 146-58 (2016)


Article DOI: 10.1016/j.bioorg.2016.02.009
BindingDB Entry DOI: 10.7270/Q2VT1QVX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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n/an/a 36n/an/an/an/an/a25



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...


US Patent US10053458 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Anaplastic lymphoma kinase C1156Y (ALK C1156Y)


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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KEGG

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PC cid
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Article
PubMed
n/an/a 133n/an/an/an/a7.525



Tianjin University of Science and Technology



Assay Description
The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...


Bioorg Chem 65: 146-58 (2016)


Article DOI: 10.1016/j.bioorg.2016.02.009
BindingDB Entry DOI: 10.7270/Q2VT1QVX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)