BindingDB BDBM179902 US10231963, Table C.6::US10287250, Compound D.6::US10736890, Compound TABLE C.6::US10752592, Compound TABLE D.6::US11534436, Compound Table C.6::US9133125, Table D, Compound 6::US9656961, Example 00170

BDBM179902 US10231963, Table C.6::US10287250, Compound D.6::US10736890, Compound TABLE C.6::US10752592, Compound TABLE D.6::US11534436, Compound Table C.6::US9133125, Table D, Compound 6::US9656961, Example 00170

SMILES NC(=O)c1ccc2C[C@@H]3C4CCCC[C@]4(CCN3CC3CCC3)c2c1

InChI Key InChIKey=GIZYPGRXWUVSHP-KXBOQVSUSA-N

Data 7 KI 7 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 179902

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nM ΔG°: -13.6kcal/mole IC50: 7.80nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

Ki: 0.0980nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

EC50: 2.5nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

EC50: 2.5nMpH: 7.4Assay Description:The EC50 and Imax for μ opioid receptors was determined using a [I35S]GTPγS binding assay. This assay measures the functional properties of a compo...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

IC50: 7.80nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

EC50: 2.5nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

EC50: 2.5nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179902(US10231963, Table C.6 | US10287250, Compound D.6 |...)

EC50: 2.5nMAssay Description:The EC50 and Imax for μ opioid receptors was determined using a [35S]GTPγS binding assay. This assay measures the functional properties of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent