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BDBM180396 US9133168, Example 9d

SMILES: FC(F)Oc1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1

InChI Key: InChIKey=WWXWCDCDJXNEGY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180396   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM180396
PNG
(US9133168, Example 9d)
Show SMILES FC(F)Oc1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1
Show InChI InChI=1S/C19H20F2N4O4/c20-19(21)29-14-3-1-2-13-12(14)4-5-25(13)18(27)10-15-22-16(11-17(26)23-15)24-6-8-28-9-7-24/h1-3,11,19H,4-10H2,(H,22,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
This test is based on measurement of the expression of AKT protein phosphorylated on serine 473 (P-AKT-S473) in the PC3 human prostate carcinoma line...


US Patent US9133168 (2015)


BindingDB Entry DOI: 10.7270/Q29W0D8X
More data for this
Ligand-Target Pair