BDBM181649 US9139577, 5.008::US9708274, 5.008

SMILES CCNC(=O)N1CCS(=O)(CC1)=Nc1cc(C)c2c(Nc3ccc(F)cc3O[C@H](C)c3cc(C)no3)ncnc2c1

InChI Key InChIKey=HCONGYLPWCJLSG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 181649   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Evotec International

US Patent
LigandPNGBDBM181649(US9708274, 5.008 | US9139577, 5.008)
Affinity DataIC50: 2nMT: 2°CAssay Description:The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Evotec International

US Patent
LigandPNGBDBM181649(US9708274, 5.008 | US9139577, 5.008)
Affinity DataIC50: 2nMAssay Description:The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM181649(US9708274, 5.008 | US9139577, 5.008)
Affinity DataIC50: 39nMAssay Description:The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM181649(US9708274, 5.008 | US9139577, 5.008)
Affinity DataIC50: 39nMpH: 7.5Assay Description:The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent