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BDBM181708 US9139585, 3

SMILES: Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(cc1)C#N

InChI Key: InChIKey=ORIRRWCFAZEYQT-STXWUKLDNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181708   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM181708
PNG
(US9139585, 3)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1/C23H23N3O5S/c1-14-19(6-7-20-21(14)13-31-23(20)28)22(27)12-25-10-17-8-16(25)11-26(17)32(29,30)18-4-2-15(9-24)3-5-18/h2-7,16-17,22,27H,8,10-13H2,1H3/t16-,17-,22-/s2
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair