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BDBM181746 US9139585, 36A

SMILES: Cc1nc(ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)-n1cnnn1

InChI Key: InChIKey=JEASHQWBJCYHJN-VXKWHMMOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM181746
PNG
(US9139585, 36A)
Show SMILES Cc1nc(ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)-n1cnnn1
Show InChI InChI=1S/C24H29N7O4/c1-15-17(3-4-19-20(15)13-35-24(19)34)21(32)11-29-7-9-30(10-8-29)12-22(33)18-5-6-23(26-16(18)2)31-14-25-27-28-31/h3-6,14,21-22,32-33H,7-13H2,1-2H3/t21-,22-/m0/s1
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Similars

US Patent
n/an/a 55n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair