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BDBM182043 US9145391, 1-10

SMILES: CCOC(=O)C1CCC(O)(CC1)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1

InChI Key: InChIKey=JHCYVDWYRVCSBL-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182043   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM182043
PNG
(US9145391, 1-10)
Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C26H27F3N4O3/c1-3-36-24(34)17-6-9-25(35,10-7-17)21-5-4-18(15-31-21)20-12-16(2)13-23(32-20)33-22-14-19(8-11-30-22)26(27,28)29/h4-5,8,11-15,17,35H,3,6-7,9-10H2,1-2H3,(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/a7.525



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...


US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair