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BDBM182224 US9145391, 4-121

SMILES: Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)CCc2nc3ccccc3s2)nc1

InChI Key: InChIKey=MQFAVAHNSDQOHJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182224   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM182224
PNG
(US9145391, 4-121)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)CCc2nc3ccccc3s2)nc1
Show InChI InChI=1S/C32H30F3N7OS/c1-20-16-25(39-29(17-20)41-28-18-22(10-13-36-28)32(33,34)35)21-6-7-27(37-19-21)38-23-11-14-42(15-12-23)31(43)9-8-30-40-24-4-2-3-5-26(24)44-30/h2-7,10,13,16-19,23H,8-9,11-12,14-15H2,1H3,(H,37,38)(H,36,39,41)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/a7.525



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...


US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair