BDBM18261 6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::Pyrrolo[2, 3-d]pyrimidine analogue, 11

SMILES CCc1c(Sc2c(Cl)cccc2Cl)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=SRGKTOIHQXANLF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18261   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandChemical structure of BindingDB Monomer ID 18261BDBM18261(6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)
Affinity DataIC50: 3.80E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandChemical structure of BindingDB Monomer ID 18261BDBM18261(6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)
Affinity DataIC50: 4.00E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandChemical structure of BindingDB Monomer ID 18261BDBM18261(6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)
Affinity DataIC50: 1.20E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandChemical structure of BindingDB Monomer ID 18261BDBM18261(6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)
Affinity DataIC50: 2.06E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

LigandChemical structure of BindingDB Monomer ID 18261BDBM18261(6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)
Affinity DataIC50: 2.80E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed