BDBM182847 US9149492, K-604

SMILES CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1

InChI Key InChIKey=VGGMTOYKEDKFLN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 182847   

TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  450nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  1.03E+5nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  26nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  450nMAssay Description:Inhibition of human ACAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  1.03E+5nMAssay Description:Inhibition of human ACAT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed