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BDBM183614 US9145354, 281

SMILES: C[C@@H](CC(N)=O)NCc1ccc(Cl)c(C(=O)c2ccccc2)c1F

InChI Key: InChIKey=RODJGUBHMZSLAX-LDGXTIHJNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183614   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM183614
PNG
(US9145354, 281)
Show SMILES C[C@@H](CC(N)=O)NCc1ccc(Cl)c(C(=O)c2ccccc2)c1F
Show InChI InChI=1/C18H18ClFN2O2/c1-11(9-15(21)23)22-10-13-7-8-14(19)16(17(13)20)18(24)12-5-3-2-4-6-12/h2-8,11,22H,9-10H2,1H3,(H2,21,23)/t11-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 450n/an/an/an/an/a25



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
The HCV NS3 protease functions have been extensively studied and are considered as potential targets for antiviral therapy: see for example the many ...


US Patent US9145354 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MMZ
More data for this
Ligand-Target Pair