BDBM183786 US9150526, 36

SMILES: COc1c(F)cc(F)cc1-c1cccc(c1)C(CC(O)=O)c1nccs1

InChI Key: InChIKey=SVVSLJKFDWXBFW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin A (CTSA) (Homo sapiens (Human))	BDBM183786 (US9150526, 36) Show SMILES COc1c(F)cc(F)cc1-c1cccc(c1)C(CC(O)=O)c1nccs1 Show InChI InChI=1S/C19H15F2NO3S/c1-25-18-14(8-13(20)9-16(18)21)11-3-2-4-12(7-11)15(10-17(23)24)19-22-5-6-26-19/h2-9,15H,10H2,1H3,(H,23,24)	PDB MMDB B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	467	n/a	n/a	n/a	n/a	6.0	37
Sanofi US Patent					Assay Description Recombinant human cathepsin A (residues 29-480, with a C-terminal 10-His tag; R&D Systems, #1049-SE) was proteolytically activated with recombinant h...				US Patent US9150526 (2015) BindingDB Entry DOI: 10.7270/Q2QR4VXP
					More data for this Ligand-Target Pair