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BDBM183786 US9150526, 36

SMILES: COc1c(F)cc(F)cc1-c1cccc(c1)C(CC(O)=O)c1nccs1

InChI Key: InChIKey=SVVSLJKFDWXBFW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183786   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM183786
PNG
(US9150526, 36)
Show SMILES COc1c(F)cc(F)cc1-c1cccc(c1)C(CC(O)=O)c1nccs1
Show InChI InChI=1S/C19H15F2NO3S/c1-25-18-14(8-13(20)9-16(18)21)11-3-2-4-12(7-11)15(10-17(23)24)19-22-5-6-26-19/h2-9,15H,10H2,1H3,(H,23,24)
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 467n/an/an/an/a6.037



Sanofi

US Patent


Assay Description
Recombinant human cathepsin A (residues 29-480, with a C-terminal 10-His tag; R&D Systems, #1049-SE) was proteolytically activated with recombinant h...


US Patent US9150526 (2015)


BindingDB Entry DOI: 10.7270/Q2QR4VXP
More data for this
Ligand-Target Pair