BDBM184016 US9150566, 53

SMILES Cc1ccc(c(n1)C(=O)N1CCOC[C@H]1Cc1cccc(c1)-n1cccn1)-n1nccn1

InChI Key InChIKey=ZITMXEDGKUYCKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 184016   

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM184016(US9150566, 53)
Affinity DataIC50: 27nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM184016(US9150566, 53)
Affinity DataIC50: 3.40E+3nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM184016(US9150566, 53)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
US Patent