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BDBM184533 US9150578, I-162

SMILES: COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC[C@@H]1CCCO1

InChI Key: InChIKey=RKWGNTHTPQXXQN-KSYWNVGFNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184533   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184533
PNG
(US9150578, I-162)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC[C@@H]1CCCO1
Show InChI InChI=1/C33H34N8O3/c1-40-19-24(17-36-40)20-6-8-21(9-7-20)31-29-27(39-41(31)2)13-11-23-16-35-33(38-30(23)29)37-26-12-10-22(15-28(26)43-3)32(42)34-18-25-5-4-14-44-25/h6-10,12,15-17,19,25H,4-5,11,13-14,18H2,1-3H3,(H,34,42)(H,35,37,38)/t25-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.390n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair