BDBM184556 US9150579, B1

SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12

InChI Key InChIKey=IUVCFHHAEHNCFT-INIZCTEOSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 184556   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50:  22.3nMT: 2°CAssay Description:The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human N-terminal His-tagged PI3Kalpha/p85alpha expressed in Spodoptera frugiperda using phosphatidylinositol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50:  48nMAssay Description:Inhibition of human PI3Kdelta using substrate PIP2:PS and ATP incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50: >120nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human full length recombinant N-terminal His-tagged PI3Kbeta/p85alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed