BDBM18510 5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenoxy}pentanoic acid::CHEMBL37520::Diaminopyrimidine, 22

SMILES: COc1ccc(cc1Cc2cnc(nc2N)N)OCCCCC(=O)O

InChI Key: InChIKey=ALDCXILJAYAUTH-UHFFFAOYSA-N

Data: 13 IC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 18510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.37E+4	n/a	n/a	n/a	n/a	7.0	25
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Dihydrofolate reductase (Rat)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Escherichia coli)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Mycobacterium avium)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Pneumocystis carinii)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Mycobacterium avium)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Rat)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM18510 (5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
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