BDBM18512 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine::CHEMBL36::Pyrimethamine (Pyr)::US11530198, Example Pyrimethamine::cid_4993

SMILES: CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1

InChI Key: InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N

Data: 42 KI  79 IC50  4 Kd  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 124 hits for monomerid = 18512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.0	25
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Streptokinase A (Streptococcus pyogenes M1 GAS)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
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Low molecular weight phosphotyrosine protein phosphatase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Low molecular weight phosphotyrosine protein phosphatase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein phosphatase non-receptor type 22 (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	275	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma brucei brucei)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	407	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Leishmania major)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.25	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Escherichia coli)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Escherichia coli)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pteridine reductase 1 (Leishmania major)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18512 (cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair