BDBM185149 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine::Crenolanib::US11542261, Compound crenolanib

SMILES: CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1

InChI Key: InChIKey=DYNHJHQFHQTFTP-UHFFFAOYSA-N

Data: 17 IC50  18 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 185149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	790	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835V] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0230	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ferrochelatase, mitochondrial [R115L] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [564-710,762-958] (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185149 (Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair