BDBM185674 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide::Rebastinib

SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1

InChI Key: InChIKey=WVXNSAVVKYZVOE-UHFFFAOYSA-N

Data: 9 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 214 hits for monomerid = 185674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [229-512] (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src [251-533] (Chicken)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Yes (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Yes (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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High affinity nerve growth factor receptor (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	737	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor-interacting serine/threonine-protein kinase 3 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
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Regulator of chromosome condensation (Homo sapiens)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Blk (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Fibroblast growth factor receptor 2 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lck (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Mer (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase 7 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Angiopoietin-1 receptor (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein-tyrosine kinase 6 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase CSK (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Discoidin domain-containing receptor 2 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-A receptor 6 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-A receptor 7 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-B receptor 4 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Fibroblast growth factor receptor 1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Fibroblast growth factor receptor 3 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fgr (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase FRK (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fyn (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase HCK (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 4 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 5 (Homo sapiens)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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LIM domain kinase 1 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 10 (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lyn (Human)	BDBM185674 (Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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