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BDBM185680 UNC10107954::US9156822, 10

SMILES: COc1ccccc1N1CCCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1

InChI Key: InChIKey=WASBJZGHAFSXQF-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 185680   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185680
PNG
(UNC10107954 | US9156822, 10)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C25H31N3O3/c1-30-24-8-3-2-7-23(24)28-15-6-14-27(16-17-28)13-4-5-18-31-21-11-9-20-10-12-25(29)26-22(20)19-21/h2-3,7-12,19H,4-6,13-18H2,1H3,(H,26,29)
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PC sid
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Similars

US Patent
2.10n/an/an/an/an/an/a7.4n/a



University of North Carolina at Chapel Hill

US Patent


Assay Description
Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185680
PNG
(UNC10107954 | US9156822, 10)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C25H31N3O3/c1-30-24-8-3-2-7-23(24)28-15-6-14-27(16-17-28)13-4-5-18-31-21-11-9-20-10-12-25(29)26-22(20)19-21/h2-3,7-12,19H,4-6,13-18H2,1H3,(H,26,29)
PDB

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UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.5n/an/a7.4n/a



University of North Carolina at Chapel Hill

US Patent


Assay Description
Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185680
PNG
(UNC10107954 | US9156822, 10)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C25H31N3O3/c1-30-24-8-3-2-7-23(24)28-15-6-14-27(16-17-28)13-4-5-18-31-21-11-9-20-10-12-25(29)26-22(20)19-21/h2-3,7-12,19H,4-6,13-18H2,1H3,(H,26,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 306n/an/a7.4n/a



University of North Carolina at Chapel Hill

US Patent


Assay Description
HEK293T cells co-expressing the cAMP biosensor GloSensor-22F (Promega) and hD2 receptors were seeded (10,000 cells/20 ul/well) into white, clear-bott...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair