BDBM18629 (18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]thiophen-2-yl}methylidene)-17-oxa-6-azatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,8,11,13,15-heptaen-13-ol::secondary alcohol, 15(+)

SMILES COc1c(O)ccc2O\C(=C/c3sccc3[C@H](O)C(F)(F)F)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=MJQKPIOTILTXNU-NDCWXWKDSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18629   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18629((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(1S)-2,2,...)
Affinity DataIC50:  0.200nM EC50:  0.200nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed