BDBM187172 US9670181, 51 1-isopropyl-6,7-dimethoxy-4-((6-methoxy-2-(2,2,2-trifluoroethylamino)quinolin-3-yl)methyl)isoquinolin-3-ol

SMILES COc1ccc2nc(NCC(F)(F)F)c(Cc3c(O)nc(C(C)C)c4cc(OC)c(OC)cc34)cc2c1

InChI Key InChIKey=PUECNZWNMCIENI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 187172   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM187172(US9670181, 51 1-isopropyl-6,7-dimethoxy-4-((6-meth...)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM187172(US9670181, 51 1-isopropyl-6,7-dimethoxy-4-((6-meth...)
Affinity DataIC50:  55nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent