BDBM187220 US9670193, 10 N-(pyridin-3-ylmethyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine
SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)nc1
InChI Key InChIKey=ALZUIFJAXCAFHL-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 187220
Affinity DataIC50: 6.60E+3nMAssay Description:Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant full length human HDAC-1 expressed in baculovirus expression system using acetyl-Gly-Ala-Lys(acetyl)-AMC as substrate after...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant full length human HDAC-6 expressed in baculovirus expression system using acetyl-Gly-Ala-Lys(acetyl)-AMC as substrate after...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human HDAC-4 (2 to 1084) expressed in baculovirus infected Sf9 cells using acetyl-Gly-Ala-Lys(E-trifluoroacetyl)-AMC as sub...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair