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BDBM187592 US9169252, 156

SMILES: CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC1)-n1ncc2cc(F)cnc12

InChI Key: InChIKey=FCJKVKVZBVEKEK-XISACWJONA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187592   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187592
PNG
(US9169252, 156)
Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC1)-n1ncc2cc(F)cnc12
Show InChI InChI=1/C20H22F2N6O2/c1-20(2,30)16(22)10-25-19(29)14-9-23-17(6-15(14)27-13-3-4-13)28-18-11(7-26-28)5-12(21)8-24-18/h5-9,13,16,30H,3-4,10H2,1-2H3,(H,23,27)(H,25,29)/t16-/s2
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.5n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair