BDBM18792 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine::CHEMBL747::Chlorazin::Cycloguanil

SMILES: CC1(N=C(N=C(N1c2ccc(cc2)Cl)N)N)C

InChI Key: InChIKey=QMNFFXRFOJIOKZ-UHFFFAOYSA-N

Data: 29 KI  13 IC50  1 Kd  1 EC50

PDB links: 7 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 18792   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Pneumocystis carinii)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Trace amine-associated receptor 5 (Mouse)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	-13.0	37	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (malaria parasite P. falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		6.20	-11.2	2.40E+3	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		31.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		55.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Chicken)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase [N51I,C59R,S108N,I164L] (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		254	-8.99	>1.00E+5	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		285	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		730	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase [A16V,S108T] (malaria parasite P. falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		2.13E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.74E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18792 (Chlorazin | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		1.09E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair