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BDBM188798 US9169260, 64

SMILES: COc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O

InChI Key: InChIKey=HIVSDGVMNSRZLC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188798   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188798
PNG
(US9169260, 64)
Show SMILES COc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H24FN7O4S/c1-35-16-4-5-20(18(24)12-16)31-21(27-23(32)17-14-26-30-9-3-8-25-22(17)30)13-19(28-31)15-6-10-29(11-7-15)36(2,33)34/h3-5,8-9,12-15H,6-7,10-11H2,1-2H3,(H,27,32)
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MMDB

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PC sid
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Similars

US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair