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BDBM188836 US9169260, 102

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(N)cc1

InChI Key: InChIKey=ABYSRHODGZLWJQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188836   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188836
PNG
(US9169260, 102)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(N)cc1
Show InChI InChI=1S/C23H19N7O/c1-15-3-9-18(10-4-15)30-21(13-20(28-30)16-5-7-17(24)8-6-16)27-23(31)19-14-26-29-12-2-11-25-22(19)29/h2-14H,24H2,1H3,(H,27,31)
PDB
MMDB

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PC sid
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Similars

US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair