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BDBM189002 US9169260, 268

SMILES: Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCc2ccncc2C1

InChI Key: InChIKey=VABMHLWBFIXZJO-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189002   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM189002
PNG
(US9169260, 268)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCc2ccncc2C1
Show InChI InChI=1/C30H31N9O/c1-20-3-6-27(33-17-20)39-28(35-30(40)25-19-34-38-12-2-10-32-29(25)38)16-26(36-39)22-8-13-37(14-9-22)24-5-4-21-7-11-31-18-23(21)15-24/h2-3,6-7,10-12,16-19,22,24H,4-5,8-9,13-15H2,1H3,(H,35,40)
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Similars

US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair