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BDBM189100 US9169260, 369

SMILES: CCCCS(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1

InChI Key: InChIKey=QMNXRIPSRGYZAO-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM189100
PNG
(US9169260, 369)
Show SMILES CCCCS(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1/C26H31N7O2S/c1-3-4-16-36(35)31-14-10-20(11-15-31)23-17-24(33(30-23)21-8-6-19(2)7-9-21)29-26(34)22-18-28-32-13-5-12-27-25(22)32/h5-9,12-13,17-18,20H,3-4,10-11,14-16H2,1-2H3,(H,29,34)
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Similars

US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair