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BDBM189122 US9169260, 391

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=RLFHDIARVVKOKQ-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189122   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM189122
PNG
(US9169260, 391)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1/C28H25Cl2N7O2S/c1-18-3-6-21(7-4-18)37-26(33-28(38)22-17-32-36-12-2-11-31-27(22)36)16-24(34-37)19-9-13-35(14-10-19)40(39)25-8-5-20(29)15-23(25)30/h2-8,11-12,15-17,19H,9-10,13-14H2,1H3,(H,33,38)
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Similars

US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair