BDBM18921 2-(3,5-dichloro-4-{4-hydroxy-3-[2-(trifluoromethyl)phenyl]phenoxy}phenyl)acetic acid::4-hydroxy thyromimetic, 9b

SMILES OC(=O)Cc1cc(Cl)c(Oc2ccc(O)c(c2)-c2ccccc2C(F)(F)F)c(Cl)c1

InChI Key InChIKey=HLQWEKCWYZMMLL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18921   

TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18921(2-(3,5-dichloro-4-{4-hydroxy-3-[2-(trifluoromethyl...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18921(2-(3,5-dichloro-4-{4-hydroxy-3-[2-(trifluoromethyl...)
Affinity DataIC50:  3.24nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18921(2-(3,5-dichloro-4-{4-hydroxy-3-[2-(trifluoromethyl...)
Affinity DataIC50:  18.2nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18921(2-(3,5-dichloro-4-{4-hydroxy-3-[2-(trifluoromethyl...)
Affinity DataIC50:  3.40nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed