BDBM189440 US9174974, Example 25

SMILES COc1cc2[C@@H](Nc3cc4ccnc(N)c4cc3F)C(=O)N(C)Cc3cc(NC(=O)OC[C@H](C)c1cc2F)ccc3S(=O)(=O)C1CC1

InChI Key InChIKey=BZFPMRWPYYLDPZ-NOVUIFNWSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189440   

TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189440(US9174974, Example 25)
Affinity DataKi:  0.25nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189440(US9174974, Example 25)
Affinity DataKi:  270nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In DepthDetails US Patent