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BDBM190066 US9175003, 251

SMILES: Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)NC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1

InChI Key: InChIKey=GCIFJYJWSLQDID-CVHSPHIUNA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 190066   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM190066
PNG
(US9175003, 251)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)NC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1
Show InChI InChI=1/C46H46Cl2N4O7/c1-26-27(2)49-17-16-35(26)30-9-6-28(7-10-30)19-38(44(54)55)50-43(53)39-20-32-21-40-41(22-33(32)23-52(39)45(56)51-46(3,4)5)59-42(25-58-40)31-11-13-34(14-12-31)57-24-29-8-15-36(47)37(48)18-29/h6-18,21-22,38-39,42H,19-20,23-25H2,1-5H3,(H,50,53)(H,51,56)(H,54,55)/t38-,39-,42+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 144n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...


US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair