BDBM190821 US9181236, 79d

SMILES Cc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C3(CC3)C(=N)N2)n1

InChI Key InChIKey=MYOKSGUEBFQLKZ-KRWDZBQOSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 190821   

TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190821(US9181236, 79d)
Affinity DataKi: <20nM ΔG°: <-10.7kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190821(US9181236, 79d)
Affinity DataKi:  30nM ΔG°:  -10.4kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
In DepthDetails US Patent