BDBM190874 US9181236, Table A, 16

SMILES C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(ccc1F)[N+]([O-])=O

InChI Key InChIKey=AMKVFRZWMZCNRI-AWEZNQCLSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 190874   

TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190874(US9181236, Table A, 16)
Affinity DataKi:  734nM ΔG°:  -8.50kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent