BDBM19130 (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide::CHEMBL99::TSA::Trichostatin A (TSA)

SMILES: CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C

InChI Key: InChIKey=ALCVRKZFLFWUAZ-UHFFFAOYSA-N

Data: 9 KI  174 IC50  2 Kd  4 EC50  1 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 189 hits for monomerid = 19130   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 6 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polyamine deacetylase HDAC10 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4E (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Plasmodium falciparum (isolate 3D7))	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	390	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2b (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Mouse)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Maize)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19130 (CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair