BDBM191488 US9181272, 258::US9181272, 270::US9181272, 271

SMILES CN1C(CCC1=O)c1cncc(c1)-c1cnc2N(CCCc2c1)C(N)=O

InChI Key InChIKey=NKCOXVQAYLNLLJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 191488   

TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191488(US9181272, 258 | US9181272, 270 | US9181272, 271)
Affinity DataIC50:  52.7nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191488(US9181272, 258 | US9181272, 270 | US9181272, 271)
Affinity DataIC50:  105nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191488(US9181272, 258 | US9181272, 270 | US9181272, 271)
Affinity DataIC50:  16.6nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent