BDBM19151 (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone::Antibiotic FR 901228::CHEMBL343448::Depsipeptide::FK228::Romidepsin

SMILES: C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C

InChI Key: InChIKey=OHRURASPPZQGQM-UHFFFAOYSA-N

Data: 39 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 19151   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	647	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polyamine deacetylase HDAC10 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.97	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Mouse)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	787	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	647	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polyamine deacetylase HDAC10 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Human)	BDBM19151 (Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair