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BDBM191590 6-phenylpteridine-2,4-diamine (35)

SMILES: Nc1nc(N)c2nc(cnc2n1)-c1ccccc1

InChI Key: InChIKey=SDGPFJCKLDWNSA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 191590   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM191590
PNG
(6-phenylpteridine-2,4-diamine (35))
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccccc1
Show InChI InChI=1S/C12H10N6/c13-10-9-11(18-12(14)17-10)15-6-8(16-9)7-4-2-1-3-5-7/h1-6H,(H4,13,14,15,17,18)
PDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.95E+4n/an/an/an/an/an/a



Max Planck Institute of Molecular Physiology



Assay Description
Single-point measurements analyses and subsequent dose-dependent investigations of selected pteridine derivatives for inhibition of CK1α were pe...


Cell Chem Biol 23: 494-507 (2016)


Article DOI: 10.1016/j.chembiol.2016.02.015
BindingDB Entry DOI: 10.7270/Q2GQ6WJD
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM191590
PNG
(6-phenylpteridine-2,4-diamine (35))
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccccc1
Show InChI InChI=1S/C12H10N6/c13-10-9-11(18-12(14)17-10)15-6-8(16-9)7-4-2-1-3-5-7/h1-6H,(H4,13,14,15,17,18)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/a7.5n/a



Max Planck Institute of Molecular Physiology



Assay Description
A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...


Cell Chem Biol 23: 494-507 (2016)


Article DOI: 10.1016/j.chembiol.2016.02.015
BindingDB Entry DOI: 10.7270/Q2GQ6WJD
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM191590
PNG
(6-phenylpteridine-2,4-diamine (35))
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccccc1
Show InChI InChI=1S/C12H10N6/c13-10-9-11(18-12(14)17-10)15-6-8(16-9)7-4-2-1-3-5-7/h1-6H,(H4,13,14,15,17,18)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.06E+4n/an/an/an/a7.5n/a



Max Planck Institute of Molecular Physiology



Assay Description
A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...


Cell Chem Biol 23: 494-507 (2016)


Article DOI: 10.1016/j.chembiol.2016.02.015
BindingDB Entry DOI: 10.7270/Q2GQ6WJD
More data for this
Ligand-Target Pair