BDBM191597 3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluoro-1H-indazol-3-yl)amino)-isonicotinic acid (N11)::US10040779, Example 73::US10336727, Example 73::US9617242, Example 73

SMILES: c1cc2c(cc1F)c(nn2CCN3CCC(CC3)(F)F)Nc4cnccc4C(=O)O

InChI Key: InChIKey=QVELLOOBNULIGQ-UHFFFAOYSA-N

Data: 12 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 191597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A [1-739] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5B [1-755] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5C [1-789] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5D [1-760] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5B [1-755] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5C [1-789] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	25
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Lysine-specific demethylase 5A [1-588] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 5B [1-604] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 5A [1-1090] (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	7.2	25
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Lysine-specific demethylase 5B (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	67	n/a	n/a	n/a	n/a	7.2	25
TBA									Citation and Details
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Lysine-specific demethylase 5C (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	7.2	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 5B (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 4C (Human)	BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
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