BDBM194780 7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one::OPC 34712::Rexulti::US9206167, 1::USRE48059, Compound of Example 1::brexpiprazole
SMILES O=c1ccc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
InChI Key InChIKey=ZKIAIYBUSXZPLP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 194780
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Cracow University Of Technology
Curated by ChEMBL
Cracow University Of Technology
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat brain hippocampus incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Displacement of [3H](+)8-OH-DPAT from human 5HT1A receptor expressed in human HeLa cells measured after 60 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO-K1 cell membranes incubated for 60 mins by microbeta scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nM ΔG°: -13.2kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]raclopride from human D2 long receptor expressed in CHO cells measured after 60 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataKi: 0.398nMAssay Description:Binding affinity to 5-HT2BR (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 0.470nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO-K1 cells measured after 20 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 0.470nMAssay Description:Displacement of [3H]-Ketanserin from human 5-HT2A receptor expressed in rat cortex tissue incubated for 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataKi: 0.510nMAssay Description:Displacement of [3H]-N-methylspiperone from D2 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scinti...More data for this Ligand-Target Pair
Affinity DataKi: 0.513nMAssay Description:Displacement of [3H]-N-methylspiperone from D2 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scinti...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nM ΔG°: -12.3kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataKi: 3.70nMAssay Description:Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Displacement of [3H]raclopride from D2 receptor in rat brain striatum incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Agonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair